{"id":47544,"date":"2021-10-02T19:34:19","date_gmt":"2021-10-02T17:34:19","guid":{"rendered":"https:\/\/www.africa-press.net\/zimbabwe\/?p=47544"},"modified":"2021-10-02T18:30:30","modified_gmt":"2021-10-02T16:30:30","slug":"natural-immunity-vs-vaccine-induced-immunity-compared-covid-19-study","status":"publish","type":"post","link":"https:\/\/www.africa-press.cc\/zimbabwe\/all-news\/natural-immunity-vs-vaccine-induced-immunity-compared-covid-19-study","title":{"rendered":"Natural Immunity Vs Vaccine-induced Immunity Compared \u2013 COVID-19 Study"},"content":{"rendered":"<p><span style=\"color: #ff6600\"><strong><a href=\"https:\/\/www.africa-press.net\/\">Africa-Press<\/a> &#8211; <a href=\"https:\/\/www.africa-press.net\/zimbabwe\">Zimbabwe<\/a>. <\/strong><\/span>A study \u201ccomparing SARS-CoV-2 natural immunity to vaccine-induced immunity: reinfections versus breakthrough infections\u201d has concluded that natural immunity confers longer-lasting and stronger protection against infection, symptomatic disease and hospitalization caused by the Delta variant of SARS-CoV-2, compared to the BNT162b2 two-dose vaccine-induced immunity.<\/p>\n<p>Background Reports of waning vaccine-induced immunity against COVID-19 have begun to surface. With that, the comparable long-term protection conferred by previous infection with SARS-CoV-2 remains unclear.<\/p>\n<p>Methods We conducted a retrospective observational study comparing three groups: (1)SARS-CoV-2-na\u00efve individuals who received a two-dose regimen of the BioNTech\/Pfizer mRNA BNT162b2 vaccine, (2) previously infected individuals who have not been vaccinated, and (3) previously infected and single-dose vaccinated individuals. Three multivariate logistic regression models were applied. In all models we evaluated four outcomes: SARS-CoV-2 infection, symptomatic disease, COVID-19-related hospitalization and death. The follow-up period of June 1 to August 14, 2021, when the Delta variant was dominant in Israel.<\/p>\n<p>Results SARS-CoV-2-na\u00efve vaccinees had a 13.06-fold (95% CI, 8.08 to 21.11) increased risk for breakthrough infection with the Delta variant compared to those previously infected, when the first event (infection or vaccination) occurred during January and February of 2021. The increased risk was significant (P&lt;0.001) for symptomatic disease as well. When allowing the infection to occur at any time before vaccination (from March 2020 to February 2021), evidence of waning natural immunity was demonstrated, though SARS-CoV-2 na\u00efve vaccinees had a 5.96-fold (95% CI, 4.85 to 7.33) increased risk for breakthrough infection and a 7.13-fold (95% CI, 5.51 to 9.21) increased risk for symptomatic disease. SARS-CoV-2-na\u00efve vaccinees were also at a greater risk for COVID-19-related-hospitalizations compared to those that were previously infected.<\/p>\n<p>Conclusions This study demonstrated that natural immunity confers longer-lasting and stronger protection against infection, symptomatic disease and hospitalization caused by the Delta variant of SARS-CoV-2, compared to the BNT162b2 two-dose vaccine-induced immunity. Individuals who were both previously infected with SARS-CoV-2 and given a single dose of the vaccine gained additional protection against the Delta variant.<\/p>\n<p>The authors have declared no competing interest.<\/p>\n<p>There was no external funding for the project.<\/p>\n<p>More: MedRxiv<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Africa-Press &#8211; Zimbabwe. A study \u201ccomparing SARS-CoV-2 natural immunity to vaccine-induced immunity: reinfections versus breakthrough infections\u201d has concluded that natural immunity confers longer-lasting and stronger protection against infection, symptomatic disease and hospitalization caused by the Delta variant of SARS-CoV-2, compared to the BNT162b2 two-dose vaccine-induced immunity. Background Reports of waning vaccine-induced immunity against COVID-19 have [&hellip;]<\/p>\n","protected":false},"author":84,"featured_media":47543,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3,1361,35,15],"tags":[1493,2189,1314,19],"class_list":{"0":"post-47544","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-all-news","8":"category-coronavirus-in-zimbabwe","9":"category-homepage-english","10":"category-twitter","11":"tag-africa-press","12":"tag-africa-press-zimbabwe-2","13":"tag-coronavirus","14":"tag-zimbabwe"},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v24.1 (Yoast SEO v24.1) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Natural Immunity Vs Vaccine-induced Immunity Compared \u2013 COVID-19 Study - zimbabwe<\/title>\n<meta name=\"description\" content=\"A study \u201ccomparing SARS-CoV-2 natural immunity to vaccine-induced immunity: reinfections versus breakthrough infections\u201d ...\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.africa-press.net\/zimbabwe\/all-news\/natural-immunity-vs-vaccine-induced-immunity-compared-covid-19-study\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Natural Immunity Vs Vaccine-induced Immunity Compared \u2013 COVID-19 Study\" \/>\n<meta property=\"og:description\" content=\"A study \u201ccomparing SARS-CoV-2 natural immunity to vaccine-induced immunity: reinfections versus breakthrough infections\u201d ...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.africa-press.net\/zimbabwe\/all-news\/natural-immunity-vs-vaccine-induced-immunity-compared-covid-19-study\" \/>\n<meta property=\"og:site_name\" content=\"zimbabwe\" \/>\n<meta property=\"article:published_time\" content=\"2021-10-02T17:34:19+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2021-10-02T16:30:30+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/static.africa-press.net\/zimbabwe\/sites\/14\/2021\/10\/img-6158890e9753a.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"675\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"cfeditoren\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"cfeditoren\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.africa-press.net\/zimbabwe\/all-news\/natural-immunity-vs-vaccine-induced-immunity-compared-covid-19-study\",\"url\":\"https:\/\/www.africa-press.net\/zimbabwe\/all-news\/natural-immunity-vs-vaccine-induced-immunity-compared-covid-19-study\",\"name\":\"Natural Immunity Vs Vaccine-induced Immunity Compared \u2013 COVID-19 Study - 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